21$33 / Opener will be busy next roll covering the blot on the five. Any hitting sevens will result in a double shot at the five point slot. Leave the indirect shot by playing 33C {Cross 2421(2), 85(2)}.
61P33 / Making the 21 point anchor is obvious. Although it is close, 33B {Both 2421(2), 1310(2)} is best. Opener's sevens aren't very strong, so we don't want to leave indirect seven shots. Note that it is slightly better to make the three point avoiding blots than the five.
  White is Player 2
score: 0 pip: 164  Unlimited Game Jacoby Beaver  pip: 167 score: 0
Blue is Player 1  
XGID=bECdEacdaB:0:0:1:33:0:0:3:0:10 
Blue to play 33 
1.  Rollout^{1}  24/21(2) 8/5(2)  eq: +0.1864 
 Player: Opponent:  53.41% (G:15.99% B:0.68%) 46.59% (G:9.79% B:0.41%)  Conf.: ±0.0036 (+0.1828...+0.1900)  [100.0%] Duration: 5 hours 42 minutes 

2.  Rollout^{1}  24/21(2) 13/10(2)  eq: +0.1556 (0.0307) 
 Player: Opponent:  53.27% (G:14.01% B:0.57%) 46.73% (G:9.92% B:0.40%)  Conf.: ±0.0030 (+0.1526...+0.1587)  [0.0%] Duration: 5 hours 54 minutes 

3.  Rollout^{2}  24/21(2) 6/3(2)  eq: +0.1501 (0.0363) 
 Player: Opponent:  52.91% (G:13.89% B:0.57%) 47.09% (G:9.69% B:0.38%)  Conf.: ±0.0040 (+0.1461...+0.1541)  [0.0%] Duration: 3 hours 28 minutes 

4.  Rollout^{3}  8/5(2) 6/3(2)  eq: +0.1386 (0.0478) 
 Player: Opponent:  52.86% (G:18.71% B:1.21%) 47.14% (G:14.50% B:0.76%)  Conf.: ±0.0057 (+0.1329...+0.1443)  [0.0%] Duration: 1 hour 30 minutes 


^{1} 31104 Games rolled with Variance Reduction. Dice Seed: 18160289 Moves and cube decisions: 3ply
^{2} 15552 Games rolled with Variance Reduction. Dice Seed: 18160289 Moves and cube decisions: 3ply
^{3} 10368 Games rolled with Variance Reduction. Dice Seed: 18160289 Moves and cube decisions: 3ply

eXtreme Gammon Version: 2.10
  White is Player 2
score: 0 pip: 160  Unlimited Game Jacoby  pip: 167 score: 0
Blue is Player 1  
XGID=bECdEbbeB:0:0:1:33:0:0:1:0:10 
Blue to play 33 
1.  Rollout^{1}  24/21(2) 13/10(2)  eq: +0.1738 
 Player: Opponent:  53.59% (G:13.96% B:0.50%) 46.41% (G:8.89% B:0.35%)  Conf.: ±0.0021 (+0.1718...+0.1759)  [100.0%] Duration: 1 day 13 hours 24 minutes 

2.  Rollout^{1}  24/21(2) 6/3(2)  eq: +0.1645 (0.0093) 
 Player: Opponent:  53.27% (G:13.94% B:0.52%) 46.73% (G:8.96% B:0.34%)  Conf.: ±0.0021 (+0.1624...+0.1665)  [0.0%] Duration: 1 day 12 hours 07 minutes 

3.  Rollout^{1}  24/21(2) 8/5(2)  eq: +0.1555 (0.0183) 
 Player: Opponent:  52.69% (G:15.13% B:0.50%) 47.31% (G:9.06% B:0.37%)  Conf.: ±0.0021 (+0.1534...+0.1576)  [0.0%] Duration: 2 days 02 hours 40 minutes 

4.  Rollout^{2}  8/5(2) 6/3(2)  eq: +0.1319 (0.0419) 
 Player: Opponent:  52.24% (G:18.28% B:0.92%) 47.76% (G:13.49% B:0.71%)  Conf.: ±0.0055 (+0.1265...+0.1374)  [0.0%] Duration: 9 hours 14 minutes 


^{1} 62208 Games rolled with Variance Reduction. Dice Seed: 57432044 Moves and cube decisions: 3ply
^{2} 10368 Games rolled with Variance Reduction. Dice Seed: 57432044 Moves and cube decisions: 3ply

eXtreme Gammon Version: 2.10